Our laboratory investigates the molecular mechanisms of gastrointestinal carcinogenesis. The lab has worked for many years on the role of inflammation in modulating stem cells and promoting gastrointestinal neoplasia using mouse models. We have defined key roles for stromal cells in tumor development, including myeloid cells, ILCs and nerves. The lab makes extensive use of transgenic/knockout mice, stem cells, lineage tracing, 3D organoids, scRNA-seq and FACS analysis of immune and epithelial cells in the gut.
Dr. Timothy Wang is a leading expert in gastroenterology cancer research and patient care. His laboratory has been continuously funded by the NIH for 29 years and by the NCI for 14 years. His lab has worked for many years on the role of inflammation in promoting gastrointestinal neoplasia, including colon cancer. His research has defined key roles for stromal cells in tumor development, including myeloid cells.
Dr. Wang is the Chief of the Division of Digestive and Liver Diseases, Silberberg Professor of Medicine and a member of the Irving Cancer Research Center. He also serves as director of the Columbia University NCI U54 Tumor Microenvironment (TMEN) program and directs the Barrett's Esophageal Translational Research Network (BETRNet) program and the Intestinal Stem Cell Consortium (ISCC) at Columbia.
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