About the Lab
Our laboratory investigates the molecular mechanisms of gastrointestinal carcinogenesis. The lab has worked for many years on the role of inflammation in modulating stem cells and promoting gastrointestinal neoplasia using mouse models. We have defined key roles for stromal cells in tumor development, including myeloid cells, ILCs and nerves. The lab makes extensive use of transgenic/knockout mice, stem cells, lineage tracing, 3D organoids, scRNA-seq and FACS analysis of immune and epithelial cells in the gut.
Areas of Interest
- Intestinal Stem Cell Niche
- Origins and progression of gastric cancer
- Immature myeloid cells in regeneration and tumor suppression
- Barrett's Esophagus
- Nerves and the Tumor Microenvironment
- Pancreatic Cancer
Timothy C. Wang
Dr. Timothy C. Wang is a leading expert in gastroenterology cancer research and patient care.
His lab has worked for many years on the role of inflammation in promoting gastrointestinal neoplasia, including colon cancer. Primarily, the research performed in his laboratory has defined key roles for stromal cells in tumor development, including myeloid cells. As an added benefit, The Wang laboratory has been continuously funded by the NIH for 30 years and by the NCI for 15 years.
Dr. Wang is a Dorothy L. and Daniel H. Silberberg Professor of Medicine and a member of the Herbert Irving Comprehensive Cancer Center.
He also serves as Co-Director of the Columbia University NCI U54 Tumor Biology and Microenvironment (TMEN) program and Director of the Barrett's Esophageal Translational Research Network (BETRNet) program and the Intestinal Stem Cell Consortium (ISCC) at Columbia.